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Interestingly, estrogen receptors ERα and ERβ are located in the axons and synaptic terminals of pre-synaptic cells and also in the dendritic spines (structures crucial for synaptic transmission) of post-synaptic cells (McEwen and Milner, 2007), indicating a role in local regulation of synapsis instead of exerting an effect at nuclear transcription (Zarate et al., 2017)