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Specifically, suppression of glycolysis can result in reduced viral replication (10)

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Despite the preclinical evidence supporting evaluation of IGF-targeted and endocrine therapy combinations, treatment with ganitumab plus the AI exemestane or ER antagonist fulvestrant did not improve PFS in women with previously treated hormone receptor-positive breast cancer, and OS was lower in the combination group versus endocrine treatment alone [197, 200]