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Although the precise significance of the differences in the pattern of CAT and GPx activity and their respective mRNA expressions in SHR and WKY rats in this study remains unclear, it is nevertheless interesting to note that the differences in renal mRNA expression and activities of CAT and, to some extent, that of GPx, between SHR and WKY rats reported in this study, became apparent before the actual rise in blood pressure in SHR

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The expression of CYP24A1 (24-hydroxylase) was significantly increased, which catabolizes both 25(OH)VD 3 and 1α,25-hydroxyvitaminD 3